Cast

Cast
Main article: List of Annedroids characters

Humans

 * Addison Holley as Anne Sagan, the title character who is a kid genius
 * Jadiel Dowlin as Nick Clegg, Anne's friend
 * Adrianna Di Liello as Shania, Anne's friend
 * James Gangl as Wilbert Sagan, Anne's father[10]
 * Raven Dauda as Maggie Clegg, Nick's mother and reporter
 * Jonny Gray as Zack, Nick's friend
 * Jayne Eastwood as Shania's grandmother
 * Joey Nijem as Garth, Shania's brother
 * Nicola Correia-Damude as Ada Turing, a scientist who was Anne's friend, and main antagonist for seasons 3 and 4
 * Devyn Nekoda as Charlie Cassini, one of Nick's science classmates
 * Colin Mochrie as Mr. Cooper, Shania's grandmother's friend
 * Naomi Sniekus as Ms. Cassini, Nick and Charlie's science teacher and Charlie's mom
 * Dylan Everett as Dylan Turing, Ada's son
 * Carson Reaume as Billy, Shania's brother
 * Aaron Feigenbaum as Ray, Shania's brother